A test that can change your dental treatment
The MELISA Test (Memory Lymphocyte Immunostimulation Assay) is a laboratory test that measures how your immune system reacts when exposed to certain metals and chemical substances. It was developed by Dr. Vera Stejskal at the Karolinska Institute in Sweden and is considered the gold standard for detecting type IV metal hypersensitivity.
How does it work?
The test analyses your T lymphocytes (immune system cells) in the presence of different metals. If your lymphocytes react excessively to a specific metal, it means your body has type IV hypersensitivity (delayed) to that material.
Unlike conventional skin prick tests (which detect type I, immediate reactions), the MELISA Test detects reactions that can take 24 to 72 hours to manifest -- exactly the type of reaction that dental metals provoke.
What is its role in dentistry?
The MELISA Test is essential before the placement of dental implants. Titanium implants contain alloys with vanadium, aluminium, and other metals that can trigger reactions in sensitive patients. If the test detects sensitivity, zirconia implants (100% ceramic, metal-free) are the safe alternative.
It is also useful for patients who have mercury amalgam fillings and suspect they may be affecting their health, or for anyone about to receive any metal restoration (crowns, bridges, brackets).
How is it performed?
It only requires a venous blood draw at the clinic -- exactly the same as a routine blood test. The sample is sent to a specialised laboratory where the reaction of your lymphocytes to a panel of metals and substances is analysed. Results are typically available within 2 to 3 weeks.
Where can I get it done in Madrid?
At Bio Salud Dental, we recommend the MELISA Test as part of our diagnostic protocol and refer the patient to a specialised laboratory. We are one of the few centres in Madrid that routinely integrates this test before implant placement.
Frequently asked questions
What you should know
No. It only requires a venous blood draw, exactly like a conventional blood test.
Approximately 2 to 3 weeks from the date of the blood draw.
In most cases, no. The MELISA Test is a specialised test that is generally not covered by public health systems or standard dental insurance plans. We recommend checking with your individual provider.
Keep reading
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